Tata Khachatrian was born on August 2, 1994, in St. Petersburg. She is fluent in four languages: English, Italian, Armenian, and Russian. In 1998, at the age of four, Tata began her studies at a music school, where she completed the piano class nine years later. In 2007, she started attending the Children's Drama School at the Conservatory, consistently being cast in leading roles while studying acting, stage speech, vocals, and dance.

In 2010, a children’s drama school was established at the State Theater of Musical Comedy. Tata, along with other students, participated in performances and concerts there. The same year, she was cast in the Mariinsky Theater’s opera "Bluebeard's Castle" playing the role of the Duke’s eldest daughter. The performance, directed by Daniel Cramer and conducted by Valery Gergiyev, was nominated for the Golden Mask Russian National Theater Award.

In 2011, Tata was cast in the state theater’s musical "Oliver Twist," where she played Charlotte and Beth, under the direction of Attila Rethly.

In 2012, Tata was offered a first leading role in the movie "The Farmer" which was created by a well-known film director.

In 2013, Tata was cast in dual roles - Princess Jasmine and a journalist - in the Theater of Musical Comedy's production of "Aladdin," directed by Wojciech Kempczinski. That summer, she enrolled at the Russian Academy of Theatre Art (GITIS) to study at the faculty for dramatic theatre and film actresses, graduating in 2017. During this period, she continued performing in plays at the Theater of Musical Comedy.

In 2019, Tata Khachatrian collaborated with Armenian theater director Karo Balyan on an independent theater project titled "Shagane. The Poet’s Secret," a one-woman show dedicated to Shagane, the muse of Russian poet Yesenin. The play premiered in October 2019 at the Hakob Paronyan State Musical Comedy Theater in Yerevan and in February 2020 at the Alexandrinsky Theater in Russia.

Khachatrian is currently touring with her one-woman show in Armenia and other countries, while also acting in movies. She received a commendation from the Ministry of Culture of Armenia for her contributions to Armenian culture and theatrical art.